Single particle cryo electron microscopy of the human serotonin transporter bound with paroxetine and in complex with 8B6 Fab
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ABSTRACT:
SUBMITTER: Jonathan Coleman
PROVIDER: EMPIAR-10380 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Chemical and structural investigation of the paroxetine-human serotonin transporter complex.
Coleman Jonathan A JA Navratna Vikas V Antermite Daniele D Yang Dongxue D Bull James A JA Gouaux Eric E
eLife 20200703
Antidepressants target the serotonin transporter (SERT) by inhibiting serotonin reuptake. Structural and biochemical studies aiming to understand binding of small-molecules to conformationally dynamic transporters like SERT often require thermostabilizing mutations and antibodies to stabilize a specific conformation, leading to questions about relationships of these structures to the bonafide conformation and inhibitor binding poses of wild-type transporter. To address these concerns, we determi ...[more]
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