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Phase-plate cryo-EM of human TFIIH

ABSTRACT:

SUBMITTER: Basil J Greber

PROVIDER: EMPIAR-10430 | biostudies-other |

REPOSITORIES: biostudies-other

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The complete structure of the human TFIIH core complex.

Greber Basil J BJ Toso Daniel B DB Fang Jie J Nogales Eva E

eLife 20190312

Transcription factor IIH (TFIIH) is a heterodecameric protein complex critical for transcription initiation by RNA polymerase II and nucleotide excision DNA repair. The TFIIH core complex is sufficient for its repair functions and harbors the XPB and XPD DNA-dependent ATPase/helicase subunits, which are affected by human disease mutations. Transcription initiation additionally requires the CdK activating kinase subcomplex. Previous structural work has provided only partial insight into the archi ...[more]

PMID: 30860024

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