Tetrameric Ptch1 complexed with ShhNp
Ontology highlight
ABSTRACT:
SUBMITTER: Nieng Yan
PROVIDER: EMPIAR-10456 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm.
Qian Hongwu H Cao Pingping P Hu Miaohui M Gao Shuai S Yan Nieng N Gong Xin X
Nature communications 20190524 1
The Hedgehog (Hh) pathway controls embryonic development and postnatal tissue maintenance and regeneration. Inhibition of Hh receptor Patched (Ptch) by the Hh ligands relieves suppression of signaling cascades. Here, we report the cryo-EM structure of tetrameric Ptch1 in complex with the palmitoylated N-terminal signaling domain of human Sonic hedgehog (ShhN<sub>p</sub>) at a 4:2 stoichiometric ratio. The structure shows that four Ptch1 protomers are organized as a loose dimer of dimers. Each di ...[more]
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