Dataset Information
Tilt-series from cryo-lamellae of WT S. cerevisiae cells
Ontology highlight
ABSTRACT:
SUBMITTER: Martin Beck
PROVIDER: EMPIAR-10466 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
In-cell architecture of the nuclear pore and snapshots of its turnover.
Nature 20200902 7831
Nuclear pore complexes (NPCs) fuse the inner and outer membranes of the nuclear envelope. They comprise hundreds of nucleoporins (Nups) that assemble into multiple subcomplexes and form large central channels for nucleocytoplasmic exchange<sup>1,2</sup>. How this architecture facilitates messenger RNA export, NPC biogenesis and turnover remains poorly understood. Here we combine in situ structural biology and integrative modelling with correlative light and electron microscopy and molecular pert ...[more]