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Human Parainfluenza Virus Fusion Complex Glycoproteins Imaged In Action On Authentic Viral Surfaces


ABSTRACT:

SUBMITTER: Tara Charlie Marcink 

PROVIDER: EMPIAR-10476 | biostudies-other |

REPOSITORIES: biostudies-other

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Human parainfluenza virus fusion complex glycoproteins imaged in action on authentic viral surfaces.

Marcink Tara C TC   Wang Tong T   des Georges Amedee A   Porotto Matteo M   Moscona Anne A  

PLoS pathogens 20200921 9


Infection by human parainfluenza viruses (HPIVs) causes widespread lower respiratory diseases, including croup, bronchiolitis, and pneumonia, and there are no vaccines or effective treatments for these viruses. HPIV3 is a member of the Respirovirus species of the Paramyxoviridae family. These viruses are pleomorphic, enveloped viruses with genomes composed of single-stranded negative-sense RNA. During viral entry, the first step of infection, the viral fusion complex, comprised of the receptor-b  ...[more]

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