Chicken CALHM1 - Human CALHM2 chimera
Ontology highlight
ABSTRACT:
SUBMITTER: Hiro Furukawa
PROVIDER: EMPIAR-10486 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structure and assembly of calcium homeostasis modulator proteins.
Syrjanen Johanna L JL Michalski Kevin K Chou Tsung-Han TH Grant Timothy T Rao Shanlin S Simorowski Noriko N Tucker Stephen J SJ Grigorieff Nikolaus N Furukawa Hiro H
Nature structural & molecular biology 20200127 2
The biological membranes of many cell types contain large-pore channels through which a wide variety of ions and metabolites permeate. Examples include connexin, innexin and pannexin, which form gap junctions and/or bona fide cell surface channels. The most recently identified large-pore channels are the calcium homeostasis modulators (CALHMs), through which ions and ATP permeate in a voltage-dependent manner to control neuronal excitability, taste signaling and pathologies of depression and Alz ...[more]
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