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Human CALHM2 in nanodisc, 1 mM EDTA

ABSTRACT:

SUBMITTER: Hiro Furukawa

PROVIDER: EMPIAR-10488 | biostudies-other |

REPOSITORIES: biostudies-other

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Structure and assembly of calcium homeostasis modulator proteins.

Syrjanen Johanna L JL Michalski Kevin K Chou Tsung-Han TH Grant Timothy T Rao Shanlin S Simorowski Noriko N Tucker Stephen J SJ Grigorieff Nikolaus N Furukawa Hiro H

Nature structural & molecular biology 20200127 2

The biological membranes of many cell types contain large-pore channels through which a wide variety of ions and metabolites permeate. Examples include connexin, innexin and pannexin, which form gap junctions and/or bona fide cell surface channels. The most recently identified large-pore channels are the calcium homeostasis modulators (CALHMs), through which ions and ATP permeate in a voltage-dependent manner to control neuronal excitability, taste signaling and pathologies of depression and Alz ...[more]

PMID: 31988524

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