Integrative imaging reveals SARS-CoV-2 induced reshaping of subcellular morphology
Ontology highlight
ABSTRACT:
SUBMITTER: Ralf Bartenschlager
PROVIDER: EMPIAR-10490 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Integrative Imaging Reveals SARS-CoV-2-Induced Reshaping of Subcellular Morphologies.
Cortese Mirko M Lee Ji-Young JY Cerikan Berati B Neufeldt Christopher J CJ Oorschot Viola M J VMJ Köhrer Sebastian S Hennies Julian J Schieber Nicole L NL Ronchi Paolo P Mizzon Giulia G Romero-Brey Inés I Santarella-Mellwig Rachel R Schorb Martin M Boermel Mandy M Mocaer Karel K Beckwith Marianne S MS Templin Rachel M RM Gross Viktoriia V Pape Constantin C Tischer Christian C Frankish Jamie J Horvat Natalie K NK Laketa Vibor V Stanifer Megan M Boulant Steeve S Ruggieri Alessia A Chatel-Chaix Laurent L Schwab Yannick Y Bartenschlager Ralf R
Cell host & microbe 20201117 6
Pathogenesis induced by SARS-CoV-2 is thought to result from both an inflammation-dominated cytokine response and virus-induced cell perturbation causing cell death. Here, we employ an integrative imaging analysis to determine morphological organelle alterations induced in SARS-CoV-2-infected human lung epithelial cells. We report 3D electron microscopy reconstructions of whole cells and subcellular compartments, revealing extensive fragmentation of the Golgi apparatus, alteration of the mitocho ...[more]
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