MscS Nanodisc with N-terminal His-Tag
Ontology highlight
ABSTRACT:
SUBMITTER: Eduardo Perozo
PROVIDER: EMPIAR-10496 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Molecular basis of force-from-lipids gating in the mechanosensitive channel MscS.
Reddy Bharat B Bavi Navid N Lu Allen A Park Yeonwoo Y Perozo Eduardo E
eLife 20191227
Prokaryotic mechanosensitive (MS) channels open by sensing the physical state of the membrane. As such, lipid-protein interactions represent the defining molecular process underlying mechanotransduction. Here, we describe cryo-electron microscopy (cryo-EM) structures of the <i>E. coli</i> small-conductance mechanosensitive channel (MscS) in nanodiscs (ND). They reveal a novel membrane-anchoring fold that plays a significant role in channel activation and establish a new location for the lipid bi ...[more]
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