Mouse cGAS with nucleosomes from 293T
Ontology highlight
ABSTRACT:
SUBMITTER: pengbiao xu
PROVIDER: EMPIAR-10511 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
The molecular basis of tight nuclear tethering and inactivation of cGAS.
Zhao Baoyu B Xu Pengbiao P Rowlett Chesley M CM Jing Tao T Shinde Omkar O Lei Yuanjiu Y West A Phillip AP Liu Wenshe Ray WR Li Pingwei P
Nature 20200910 7835
Nucleic acids derived from pathogens induce potent innate immune responses<sup>1-6</sup>. Cyclic GMP-AMP synthase (cGAS) is a double-stranded DNA sensor that catalyses the synthesis of the cyclic dinucleotide cyclic GMP-AMP, which mediates the induction of type I interferons through the STING-TBK1-IRF3 signalling axis<sup>7-11</sup>. cGAS was previously thought to not react with self DNA owing to its cytosolic localization<sup>2,12,13</sup>; however, recent studies have shown that cGAS is locali ...[more]
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