Ontology highlight
ABSTRACT:
SUBMITTER: Yulei Wang
PROVIDER: EMPIAR-10512 | biostudies-other |
REPOSITORIES: biostudies-other
Kostyuchenko Victor A VA Chew Pau Ling PL Ng Thiam-Seng TS Lok Shee-Mei SM
Journal of virology 20131023 1
Dengue virus (DENV), a mosquito-borne virus, is responsible for millions of cases of infections worldwide. There are four DENV serotypes (DENV1 to -4). After a primary DENV infection, the antibodies elicited confer lifetime protection against that DENV serotype. However, in a secondary infection with another serotype, the preexisting antibodies may cause antibody-dependent enhancement (ADE) of infection of macrophage cells, leading to the development of the more severe form of disease, dengue he ...[more]