Ontology highlight
ABSTRACT:
SUBMITTER: James Fraser
PROVIDER: EMPIAR-10523 | biostudies-other |
REPOSITORIES: biostudies-other
Nature 20200923 7827
Natural products serve as chemical blueprints for most antibiotics in clinical use. The evolutionary process by which these molecules arise is inherently accompanied by the co-evolution of resistance mechanisms that shorten the clinical lifetime of any given class of antibiotics<sup>1</sup>. Virginiamycin acetyltransferase (Vat) enzymes are resistance proteins that provide protection against streptogramins<sup>2</sup>, potent antibiotics against Gram-positive bacteria that inhibit the bacterial ...[more]