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E. coli 50S ribosome bound to compounds 47 and VS1


ABSTRACT:

SUBMITTER: James Fraser 

PROVIDER: EMPIAR-10528 | biostudies-other |

REPOSITORIES: biostudies-other

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Publications


Natural products serve as chemical blueprints for most antibiotics in clinical use. The evolutionary process by which these molecules arise is inherently accompanied by the co-evolution of resistance mechanisms that shorten the clinical lifetime of any given class of antibiotics<sup>1</sup>. Virginiamycin acetyltransferase (Vat) enzymes are resistance proteins that provide protection against streptogramins<sup>2</sup>, potent antibiotics against Gram-positive bacteria that inhibit the bacterial  ...[more]

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