SARS-CoV-2 infection in human adult lung alveolar stem cells
Ontology highlight
ABSTRACT:
SUBMITTER: Joo-Hyeon Lee
PROVIDER: EMPIAR-10533 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Three-Dimensional Human Alveolar Stem Cell Culture Models Reveal Infection Response to SARS-CoV-2.
Youk Jeonghwan J Kim Taewoo T Evans Kelly V KV Jeong Young-Il YI Hur Yongsuk Y Hong Seon Pyo SP Kim Je Hyoung JH Yi Kijong K Kim Su Yeon SY Na Kwon Joong KJ Bleazard Thomas T Kim Ho Min HM Fellows Mick M Mahbubani Krishnaa T KT Saeb-Parsy Kourosh K Kim Seon Young SY Kim Young Tae YT Koh Gou Young GY Choi Byeong-Sun BS Ju Young Seok YS Lee Joo-Hyeon JH
Cell stem cell 20201021 6
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the cause of a present pandemic, infects human lung alveolar type 2 (hAT2) cells. Characterizing pathogenesis is crucial for developing vaccines and therapeutics. However, the lack of models mirroring the cellular physiology and pathology of hAT2 cells limits the study. Here, we develop a feeder-free, long-term, three-dimensional (3D) culture technique for hAT2 cells derived from primary human lung tissue and investigate infe ...[more]
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