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Single particle cryo-EM dataset for MlaFEDB from E. coli in nanodisc

ABSTRACT:

SUBMITTER: Nicolas Coudray

PROVIDER: EMPIAR-10536 | biostudies-other |

REPOSITORIES: biostudies-other

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Structure of bacterial phospholipid transporter MlaFEDB with substrate bound.

Coudray Nicolas N Isom Georgia L GL MacRae Mark R MR Saiduddin Mariyah N MN Bhabha Gira G Ekiert Damian C DC

eLife 20201125

In double-membraned bacteria, phospholipid transport across the cell envelope is critical to maintain the outer membrane barrier, which plays a key role in virulence and antibiotic resistance. An MCE transport system called Mla has been implicated in phospholipid trafficking and outer membrane integrity, and includes an ABC transporter, MlaFEDB. The transmembrane subunit, MlaE, has minimal sequence similarity to other transporters, and the structure of the entire inner-membrane MlaFEDB complex r ...[more]

PMID: 33236984

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