Dataset Information
Single particle cryo-EM dataset for MlaFEDB from E. coli in nanodisc
Ontology highlight
ABSTRACT:
SUBMITTER: Nicolas Coudray
PROVIDER: EMPIAR-10536 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structure of bacterial phospholipid transporter MlaFEDB with substrate bound.
eLife 20201125
In double-membraned bacteria, phospholipid transport across the cell envelope is critical to maintain the outer membrane barrier, which plays a key role in virulence and antibiotic resistance. An MCE transport system called Mla has been implicated in phospholipid trafficking and outer membrane integrity, and includes an ABC transporter, MlaFEDB. The transmembrane subunit, MlaE, has minimal sequence similarity to other transporters, and the structure of the entire inner-membrane MlaFEDB complex r ...[more]