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Cryo EM strutcture of the full-length WzmWzt ABC transporter required for lipid-linked O antigen transport

ABSTRACT:

SUBMITTER: Jochen Zimmer

PROVIDER: EMPIAR-10558 | biostudies-other |

REPOSITORIES: biostudies-other

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Cryo-EM structure of the full-length WzmWzt ABC transporter required for lipid-linked O antigen transport.

Caffalette Christopher A CA Zimmer Jochen J

Proceedings of the National Academy of Sciences of the United States of America 20201221 1

O antigens are important cell surface polysaccharides in gram-negative bacteria where they extend core lipopolysaccharides in the extracellular leaflet of the outer membrane. O antigen structures are serotype specific and form extended cell surface barriers endowing many pathogens with survival benefits. In the ABC transporter-dependent biosynthesis pathway, O antigens are assembled on the cytosolic side of the inner membrane on a lipid anchor and reoriented to the periplasmic leaflet by the cha ...[more]

PMID: 33443152

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Cryo-EM structure of the full-length WzmWzt ABC transporter required for lipid-linked O antigen transport.

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