Cryo-EM structures of Helicobacter pylori vacuolating cytotoxin A (VacA) oligomeric assemblies
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ABSTRACT:
SUBMITTER: Kaiming Zhang
PROVIDER: EMPIAR-10607 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Cryo-EM structures of <i>Helicobacter pylori</i> vacuolating cytotoxin A oligomeric assemblies at near-atomic resolution.
Zhang Kaiming K Zhang Huawei H Li Shanshan S Pintilie Grigore D GD Mou Tung-Chung TC Gao Yuanzhu Y Zhang Qinfen Q van den Bedem Henry H Schmid Michael F MF Au Shannon Wing Ngor SWN Chiu Wah W
Proceedings of the National Academy of Sciences of the United States of America 20190320 14
Human gastric pathogen <i>Helicobacter pylori</i> (<i>H. pylori</i>) is the primary risk factor for gastric cancer and is one of the most prevalent carcinogenic infectious agents. Vacuolating cytotoxin A (VacA) is a key virulence factor secreted by <i>H. pylori</i> and induces multiple cellular responses. Although structural and functional studies of VacA have been extensively performed, the high-resolution structure of a full-length VacA protomer and the molecular basis of its oligomerization a ...[more]
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