Dataset Information
Unaligned movies for FA core complex and symmetric complex
Ontology highlight
ABSTRACT:
SUBMITTER: Lori A Passmore
PROVIDER: EMPIAR-10608 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structure of the Fanconi anaemia monoubiquitin ligase complex.
Nature 20191030 7781
The Fanconi anaemia (FA) pathway repairs DNA damage caused by endogenous and chemotherapy-induced DNA crosslinks, and responds to replication stress<sup>1,2</sup>. Genetic inactivation of this pathway by mutation of genes encoding FA complementation group (FANC) proteins impairs development, prevents blood production and promotes cancer<sup>1,3</sup>. The key molecular step in the FA pathway is the monoubiquitination of a pseudosymmetric heterodimer of FANCD2-FANCI<sup>4,5</sup> by the FA core c ...[more]