CryoEM structure of the LCD of hnRNPA2 amyloid-like fibrils
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ABSTRACT:
SUBMITTER: Jiahui Lu
PROVIDER: EMPIAR-10634 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid.
Lu Jiahui J Cao Qin Q Hughes Michael P MP Sawaya Michael R MR Boyer David R DR Cascio Duilio D Eisenberg David S DS
Nature communications 20200814 1
hnRNPA2 is a human ribonucleoprotein (RNP) involved in RNA metabolism. It forms fibrils both under cellular stress and in mutated form in neurodegenerative conditions. Previous work established that the C-terminal low-complexity domain (LCD) of hnRNPA2 fibrillizes under stress, and missense mutations in this domain are found in the disease multisystem proteinopathy (MSP). However, little is known at the atomic level about the hnRNPA2 LCD structure that is involved in those processes and how dise ...[more]
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