The Myosin II Coiled Coil Domain Atomic Structure in its Native Environment
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ABSTRACT:
SUBMITTER: Kenneth Taylor
PROVIDER: EMPIAR-10675 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
The myosin II coiled-coil domain atomic structure in its native environment.
Rahmani Hamidreza H Ma Wen W Hu Zhongjun Z Daneshparvar Nadia N Taylor Dianne W DW McCammon J Andrew JA Irving Thomas C TC Edwards Robert J RJ Taylor Kenneth A KA
Proceedings of the National Academy of Sciences of the United States of America 20210401 14
The atomic structure of the complete myosin tail within thick filaments isolated from <i>Lethocerus indicus</i> flight muscle is described and compared to crystal structures of recombinant, human cardiac myosin tail segments. Overall, the agreement is good with three exceptions: the proximal S2, in which the filament has heads attached but the crystal structure doesn't, and skip regions 2 and 4. At the head-tail junction, the tail α-helices are asymmetrically structured encompassing well-defined ...[more]
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