Dataset Information
Cryo electron tomography of FIB-milled lamella of human DLD-1 cells
Ontology highlight
ABSTRACT:
SUBMITTER: Ohad Medalia
PROVIDER: EMPIAR-10701 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
The cellular environment shapes the nuclear pore complex architecture.
Nature 20211013 7882
Nuclear pore complexes (NPCs) create large conduits for cargo transport between the nucleus and cytoplasm across the nuclear envelope (NE)<sup>1-3</sup>. These multi-megadalton structures are composed of about thirty different nucleoporins that are distributed in three main substructures (the inner, cytoplasmic and nucleoplasmic rings) around the central transport channel<sup>4-6</sup>. Here we use cryo-electron tomography on DLD-1 cells that were prepared using cryo-focused-ion-beam milling to ...[more]