Distinct mechanisms of the human mitoribosome recycling and antibiotic resistance
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ABSTRACT:
SUBMITTER: Rajendra K Agrawal
PROVIDER: EMPIAR-10703 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Distinct mechanisms of the human mitoribosome recycling and antibiotic resistance.
Koripella Ravi Kiran RK Deep Ayush A Agrawal Ekansh K EK Keshavan Pooja P Banavali Nilesh K NK Agrawal Rajendra K RK
Nature communications 20210614 1
Ribosomes are recycled for a new round of translation initiation by dissociation of ribosomal subunits, messenger RNA and transfer RNA from their translational post-termination complex. Here we present cryo-EM structures of the human 55S mitochondrial ribosome (mitoribosome) and the mitoribosomal large 39S subunit in complex with mitoribosome recycling factor (RRF<sub>mt</sub>) and a recycling-specific homolog of elongation factor G (EF-G2<sub>mt</sub>). These structures clarify an unusual role ...[more]
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