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Human melatonin receptor MT1 - Gi1 complex


ABSTRACT:

SUBMITTER: Osamu Nureki 

PROVIDER: EMPIAR-10714 | biostudies-other |

REPOSITORIES: biostudies-other

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Publications


Melatonin receptors (MT<sub>1</sub> and MT<sub>2</sub>) transduce inhibitory signaling by melatonin (N-acetyl-5-methoxytryptamine), which is associated with sleep induction and circadian rhythm modulation. Although recently reported crystal structures of ligand-bound MT<sub>1</sub> and MT<sub>2</sub> elucidated the basis of ligand entry and recognition, the ligand-induced MT<sub>1</sub> rearrangement leading to G<sub>i</sub>-coupling remains unclear. Here we report a cryo-EM structure of the hum  ...[more]

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