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Cryo-EM structures of engineered active bc1-cbb3 type CIII2CIV super-complexes and electronic communication between the complexes


ABSTRACT:

SUBMITTER: Fevzi Daldal 

PROVIDER: EMPIAR-10735 | biostudies-other |

REPOSITORIES: biostudies-other

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Cryo-EM structures of engineered active bc<sub>1</sub>-cbb<sub>3</sub> type CIII<sub>2</sub>CIV super-complexes and electronic communication between the complexes.

Steimle Stefan S   van Eeuwen Trevor T   Ozturk Yavuz Y   Kim Hee Jong HJ   Braitbard Merav M   Selamoglu Nur N   Garcia Benjamin A BA   Schneidman-Duhovny Dina D   Murakami Kenji K   Daldal Fevzi F  

Nature communications 20210210 1


Respiratory electron transport complexes are organized as individual entities or combined as large supercomplexes (SC). Gram-negative bacteria deploy a mitochondrial-like cytochrome (cyt) bc<sub>1</sub> (Complex III, CIII<sub>2</sub>), and may have specific cbb<sub>3</sub>-type cyt c oxidases (Complex IV, CIV) instead of the canonical aa<sub>3</sub>-type CIV. Electron transfer between these complexes is mediated by soluble (c<sub>2</sub>) and membrane-anchored (c<sub>y</sub>) cyts. Here, we repo  ...[more]

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