Dataset Information
Cryo-EM of the human insulin receptor ectodomain in complex with an insulin analog with truncated B chain and enlongated A chain
Ontology highlight
ABSTRACT:
SUBMITTER: Alan D Blakely
PROVIDER: EMPIAR-10736 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Symmetric and asymmetric receptor conformation continuum induced by a new insulin.
Nature chemical biology 20220314 5
Cone snail venoms contain a wide variety of bioactive peptides, including insulin-like molecules with distinct structural features, binding modes and biochemical properties. Here, we report an active humanized cone snail venom insulin with an elongated A chain and a truncated B chain, and use cryo-electron microscopy (cryo-EM) and protein engineering to elucidate its interactions with the human insulin receptor (IR) ectodomain. We reveal how an extended A chain can compensate for deletion of B-c ...[more]