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Cryo-EM of Mechanosensitive Ion Channel Flycatcher1 in GDN


ABSTRACT:

SUBMITTER: Sebastian Jojoa-Cruz 

PROVIDER: EMPIAR-10740 | biostudies-other |

REPOSITORIES: biostudies-other

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Structural insights into the Venus flytrap mechanosensitive ion channel Flycatcher1.

Jojoa-Cruz Sebastian S   Saotome Kei K   Tsui Che Chun Alex CCA   Lee Wen-Hsin WH   Sansom Mark S P MSP   Murthy Swetha E SE   Patapoutian Ardem A   Ward Andrew B AB  

Nature communications 20220214 1


Flycatcher1 (FLYC1), a MscS homolog, has recently been identified as a candidate mechanosensitive (MS) ion channel involved in Venus flytrap prey recognition. FLYC1 is a larger protein and its sequence diverges from previously studied MscS homologs, suggesting it has unique structural features that contribute to its function. Here, we characterize FLYC1 by cryo-electron microscopy, molecular dynamics simulations, and electrophysiology. Akin to bacterial MscS and plant MSL1 channels, we find that  ...[more]

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