Cryo-EM of Mechanosensitive Ion Channel Flycatcher1 in GDN
Ontology highlight
ABSTRACT:
SUBMITTER: Sebastian Jojoa-Cruz
PROVIDER: EMPIAR-10740 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structural insights into the Venus flytrap mechanosensitive ion channel Flycatcher1.
Jojoa-Cruz Sebastian S Saotome Kei K Tsui Che Chun Alex CCA Lee Wen-Hsin WH Sansom Mark S P MSP Murthy Swetha E SE Patapoutian Ardem A Ward Andrew B AB
Nature communications 20220214 1
Flycatcher1 (FLYC1), a MscS homolog, has recently been identified as a candidate mechanosensitive (MS) ion channel involved in Venus flytrap prey recognition. FLYC1 is a larger protein and its sequence diverges from previously studied MscS homologs, suggesting it has unique structural features that contribute to its function. Here, we characterize FLYC1 by cryo-electron microscopy, molecular dynamics simulations, and electrophysiology. Akin to bacterial MscS and plant MSL1 channels, we find that ...[more]
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