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Proton-powered peptide transporter SbmA in lipid nanodisc

ABSTRACT:

SUBMITTER: Konstantinos Beis

PROVIDER: EMPIAR-10763 | biostudies-other |

REPOSITORIES: biostudies-other

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Molecular mechanism of SbmA, a promiscuous transporter exploited by antimicrobial peptides.

Ghilarov Dmitry D Inaba-Inoue Satomi S Stepien Piotr P Qu Feng F Michalczyk Elizabeth E Pakosz Zuzanna Z Nomura Norimichi N Ogasawara Satoshi S Walker Graham Charles GC Rebuffat Sylvie S Iwata So S Heddle Jonathan Gardiner JG Beis Konstantinos K

Science advances 20210908 37

Antibiotic metabolites and antimicrobial peptides mediate competition between bacterial species. Many of them hijack inner and outer membrane proteins to enter cells. Sensitivity of enteric bacteria to multiple peptide antibiotics is controlled by the single inner membrane protein SbmA. To establish the molecular mechanism of peptide transport by SbmA and related BacA, we determined their cryo–electron microscopy structures at 3.2 and 6 Å local resolution, respectively. The structures show a pre ...[more]

PMID: 34516884

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