Single particle cryo-EM of human mitochondrial ribosomes from Pde12 KO cells
Ontology highlight
ABSTRACT:
SUBMITTER: Viswanathan Chandrasekaran
PROVIDER: EMPIAR-10809 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Elongational stalling activates mitoribosome-associated quality control.
Desai Nirupa N Yang Hanting H Chandrasekaran Viswanathan V Kazi Razina R Minczuk Michal M Ramakrishnan V V
Science (New York, N.Y.) 20201101 6520
The human mitochondrial ribosome (mitoribosome) and associated proteins regulate the synthesis of 13 essential subunits of the oxidative phosphorylation complexes. We report the discovery of a mitoribosome-associated quality control pathway that responds to interruptions during elongation, and we present structures at 3.1- to 3.3-angstrom resolution of mitoribosomal large subunits trapped during ribosome rescue. Release factor homolog C12orf65 (mtRF-R) and RNA binding protein C6orf203 (MTRES1) e ...[more]
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