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Cryo-electron microscopy reconstruction of leukotriene C4 bound bovine MRP1

ABSTRACT:

SUBMITTER: Jue Chen

PROVIDER: EMPIAR-10813 | biostudies-other |

REPOSITORIES: biostudies-other

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Structural Basis of Substrate Recognition by the Multidrug Resistance Protein MRP1.

Johnson Zachary Lee ZL Chen Jue J

Cell 20170223 6

The multidrug resistance protein MRP1 is an ATP-binding cassette (ABC) transporter that confers resistance to many anticancer drugs and plays a role in the disposition and efficacy of several opiates, antidepressants, statins, and antibiotics. In addition, MRP1 regulates redox homeostasis, inflammation, and hormone secretion. Using electron cryomicroscopy, we determined the molecular structures of bovine MRP1 in two conformations: an apo form at 3.5 Å without any added substrate and a complex fo ...[more]

PMID: 28238471

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