Dataset Information
CryoEM single particle dataset of delta-latroinsectotoxin dimer
Ontology highlight
ABSTRACT:
SUBMITTER: Minghao Chen
PROVIDER: EMPIAR-10828 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Molecular architecture of black widow spider neurotoxins.
Nature communications 20211129 1
Latrotoxins (LaTXs) are presynaptic pore-forming neurotoxins found in the venom of Latrodectus spiders. The venom contains a toxic cocktail of seven LaTXs, with one of them targeting vertebrates (α-latrotoxin (α-LTX)), five specialized on insects (α, β, γ, δ, ε- latroinsectotoxins (LITs), and one on crustaceans (α-latrocrustatoxin (α-LCT)). LaTXs bind to specific receptors on the surface of neuronal cells, inducing the release of neurotransmitters either by directly stimulating exocytosis or by ...[more]