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Structure of pathological TDP-43 filaments from ALS with FTLD (Individual 2, frontal cortex)

ABSTRACT:

SUBMITTER: Benjamin Falcon

PROVIDER: EMPIAR-10832 | biostudies-other |

REPOSITORIES: biostudies-other

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Structure of pathological TDP-43 filaments from ALS with FTLD.

Arseni Diana D Hasegawa Masato M Murzin Alexey G AG Kametani Fuyuki F Arai Makoto M Yoshida Mari M Ryskeldi-Falcon Benjamin B

Nature 20211208 7891

The abnormal aggregation of TAR DNA-binding protein 43 kDa (TDP-43) in neurons and glia is the defining pathological hallmark of the neurodegenerative disease amyotrophic lateral sclerosis (ALS) and multiple forms of frontotemporal lobar degeneration (FTLD)<sup>1,2</sup>. It is also common in other diseases, including Alzheimer's and Parkinson's. No disease-modifying therapies exist for these conditions and early diagnosis is not possible. The structures of pathological TDP-43 aggregates are unk ...[more]

PMID: 34880495

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