Ontology highlight
ABSTRACT:
SUBMITTER: Benjamin Falcon
PROVIDER: EMPIAR-10832 | biostudies-other |
REPOSITORIES: biostudies-other
Arseni Diana D Hasegawa Masato M Murzin Alexey G AG Kametani Fuyuki F Arai Makoto M Yoshida Mari M Ryskeldi-Falcon Benjamin B
Nature 20211208 7891
The abnormal aggregation of TAR DNA-binding protein 43 kDa (TDP-43) in neurons and glia is the defining pathological hallmark of the neurodegenerative disease amyotrophic lateral sclerosis (ALS) and multiple forms of frontotemporal lobar degeneration (FTLD)<sup>1,2</sup>. It is also common in other diseases, including Alzheimer's and Parkinson's. No disease-modifying therapies exist for these conditions and early diagnosis is not possible. The structures of pathological TDP-43 aggregates are unk ...[more]