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Reconstructed cryo soft X-ray tomography dataset of a treated NIH-3T3 cell with corresponding correlated cryo-3D-SIM channels


ABSTRACT:

SUBMITTER: Johannes Groen 

PROVIDER: EMPIAR-10839 | biostudies-other |

REPOSITORIES: biostudies-other

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Correlative 3D cryo X-ray imaging reveals intracellular location and effect of designed antifibrotic protein-nanomaterial hybrids.

Groen J J   Palanca A A   Aires A A   Conesa J J JJ   Maestro D D   Rehbein S S   Harkiolaki M M   Villar A V AV   Cortajarena A L AL   Pereiro E E  

Chemical science 20211019 45


Revealing the intracellular location of novel therapeutic agents is paramount for the understanding of their effect at the cell ultrastructure level. Here, we apply a novel correlative cryo 3D imaging approach to determine the intracellular fate of a designed protein-nanomaterial hybrid with antifibrotic properties that shows great promise in mitigating myocardial fibrosis. Cryo 3D structured illumination microscopy (cryo-3D-SIM) pinpoints the location and cryo soft X-ray tomography (cryo-SXT) r  ...[more]

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