Dataset Information
Cryo electron microscopy of hIAPP fibrils seeded by patient-extracted fibrils
Ontology highlight
ABSTRACT:
SUBMITTER: Qin Cao
PROVIDER: EMPIAR-10868 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores.
Nature structural & molecular biology 20210909 9
Amyloidosis of human islet amyloid polypeptide (hIAPP) is a pathological hallmark of type II diabetes (T2D), an epidemic afflicting nearly 10% of the world's population. To visualize disease-relevant hIAPP fibrils, we extracted amyloid fibrils from islet cells of a T2D donor and amplified their quantity by seeding synthetic hIAPP. Cryo-EM studies revealed four fibril polymorphic atomic structures. Their resemblance to four unseeded hIAPP fibrils varies from nearly identical (TW3) to non-existent ...[more]