Ontology highlight
ABSTRACT:
SUBMITTER: John Francis Hunt
PROVIDER: EMPIAR-10872 | biostudies-other |
REPOSITORIES: biostudies-other
Li Yaohui Y Zhang Rongzhen R Wang Chi C Forouhar Farhad F Clarke Oliver B OB Vorobiev Sergey S Singh Shikha S Montelione Gaetano T GT Szyperski Thomas T Xu Yan Y Hunt John F JF
The EMBO journal 20220708 17
The evolutionary benefit accounting for widespread conservation of oligomeric structures in proteins lacking evidence of intersubunit cooperativity remains unclear. Here, crystal and cryo-EM structures, and enzymological data, demonstrate that a conserved tetramer interface maintains the active-site structure in one such class of proteins, the short-chain dehydrogenase/reductase (SDR) superfamily. Phylogenetic comparisons support a significantly longer polypeptide being required to maintain an e ...[more]