Dataset Information
Structure of the ligand-free GPCR dimer Ste2
Ontology highlight
ABSTRACT:
SUBMITTER: Christopher Gordon Tate
PROVIDER: EMPIAR-10878 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Activation mechanism of the class D fungal GPCR dimer Ste2.
Nature 20220316 7902
The fungal class D1 G-protein-coupled receptor (GPCR) Ste2 has a different arrangement of transmembrane helices compared with mammalian GPCRs and a distinct mode of coupling to the heterotrimeric G protein Gpa1-Ste2-Ste18<sup>1</sup>. In addition, Ste2 lacks conserved sequence motifs such as DRY, PIF and NPXXY, which are associated with the activation of class A GPCRs<sup>2</sup>. This suggested that the activation mechanism of Ste2 may also differ. Here we determined structures of Saccharomyces ...[more]