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Cryo-EM SPA dataset of Megadalton-range protein communities from a Chaetomium thermophilum native cell extract

ABSTRACT:

SUBMITTER: Panagiotis L. Kastritis

PROVIDER: EMPIAR-10892 | biostudies-other |

REPOSITORIES: biostudies-other

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Cryo-EM and artificial intelligence visualize endogenous protein community members.

Skalidis Ioannis I Kyrilis Fotis L FL Tüting Christian C Hamdi Farzad F Chojnowski Grzegorz G Kastritis Panagiotis L PL

Structure (London, England : 1993) 20220131 4

Cellular function is underlined by megadalton assemblies organizing in proximity, forming communities. Metabolons are protein communities involving metabolic pathways such as protein, fatty acid, and thioesters of coenzyme-A synthesis. Metabolons are highly heterogeneous due to their function, making their analysis particularly challenging. Here, we simultaneously characterize metabolon-embedded architectures of a 60S pre-ribosome, fatty acid synthase, and pyruvate/oxoglutarate dehydrogenase com ...[more]

PMID: 35093201

Publication: 1/2

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