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Motion corrected micrographs - purified Dot/Icm T4SS particles

ABSTRACT:

SUBMITTER: Melanie Ohi

PROVIDER: EMPIAR-10893 | biostudies-other |

REPOSITORIES: biostudies-other

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Structural analysis of the <i>Legionella pneumophila</i> Dot/Icm type IV secretion system core complex.

Durie Clarissa L CL Sheedlo Michael J MJ Chung Jeong Min JM Byrne Brenda G BG Su Min M Knight Thomas T Swanson Michele M Lacy D Borden DB Ohi Melanie D MD

eLife 20200902

<i>Legionella pneumophila</i> is an opportunistic pathogen that causes the potentially fatal pneumonia Legionnaires' Disease. This infection and subsequent pathology require the Dot/Icm Type IV Secretion System (T4SS) to deliver effector proteins into host cells. Compared to prototypical T4SSs, the Dot/Icm assembly is much larger, containing ~27 different components including a core complex reported to be composed of five proteins: DotC, DotD, DotF, DotG, and DotH. Using single particle cryo-ele ...[more]

PMID: 32876045

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