Dataset Information
Single particle cryo-EM dataset of Mus musculus mitochondrial complex I bound with an acetogenin inhibitor
Ontology highlight
ABSTRACT:
SUBMITTER: Judy Hirst
PROVIDER: EMPIAR-10927 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Cryo-electron microscopy reveals how acetogenins inhibit mitochondrial respiratory complex I.
The Journal of biological chemistry 20220119 3
Mitochondrial complex I (NADH:ubiquinone oxidoreductase), a crucial enzyme in energy metabolism, captures the redox potential energy from NADH oxidation/ubiquinone reduction to create the proton motive force used to drive ATP synthesis in oxidative phosphorylation. High-resolution single-particle electron cryo-EM analyses have provided detailed structural knowledge of the catalytic machinery of complex I, but not of the molecular principles of its energy transduction mechanism. Although ubiquino ...[more]