Cryo-EM structures of monomeric and dimeric human somatic angiotensin I-converting enzyme (apo form)
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ABSTRACT:
SUBMITTER: Lizelle Lubbe
PROVIDER: EMPIAR-10980 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Cryo-EM reveals mechanisms of angiotensin I-converting enzyme allostery and dimerization.
Lubbe Lizelle L Sewell Bryan Trevor BT Woodward Jeremy D JD Sturrock Edward D ED
The EMBO journal 20220712 16
Hypertension (high blood pressure) is a major risk factor for cardiovascular disease, which is the leading cause of death worldwide. The somatic isoform of angiotensin I-converting enzyme (sACE) plays a critical role in blood pressure regulation, and ACE inhibitors are thus widely used to treat hypertension and cardiovascular disease. Our current understanding of sACE structure, dynamics, function, and inhibition has been limited because truncated, minimally glycosylated forms of sACE are typica ...[more]
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