Dataset Information
Cryo-EM micrographs of BMV TLS RNA
Ontology highlight
ABSTRACT:
SUBMITTER: Jeffrey S. Kieft
PROVIDER: EMPIAR-10993 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
A viral RNA hijacks host machinery using dynamic conformational changes of a tRNA-like structure.
Science (New York, N.Y.) 20211118 6570
Viruses require multifunctional structured RNAs to hijack their host’s biochemistry, but their mechanisms can be obscured by the difficulty of solving conformationally dynamic RNA structures. Using cryo–electron microscopy (cryo-EM), we visualized the structure of the mysterious viral transfer RNA (tRNA)–like structure (TLS) from the brome mosaic virus, which affects replication, translation, and genome encapsidation. Structures in isolation and those bound to tyrosyl-tRNA synthetase (TyrRS) sho ...[more]