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Cryogenic electron microscopy structure of full length human meta vinculin

ABSTRACT:

SUBMITTER: Tina Izard

PROVIDER: EMPIAR-11029 | biostudies-other |

REPOSITORIES: biostudies-other

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The Cryogenic Electron Microscopy Structure of the Cell Adhesion Regulator Metavinculin Reveals an Isoform-Specific Kinked Helix in Its Cytoskeleton Binding Domain.

Rangarajan Erumbi S ES Izard Tina T

International journal of molecular sciences 20210111 2

Vinculin and its heart-specific splice variant metavinculin are key regulators of cell adhesion processes. These membrane-bound cytoskeletal proteins regulate the cell shape by binding to several other proteins at cell-cell and cell-matrix junctions. Vinculin and metavinculin link integrin adhesion molecules to the filamentous actin network. Loss of both proteins prevents cell adhesion and cell spreading and reduces the formation of stress fibers, focal adhesions, or lamellipodia extensions. The ...[more]

PMID: 33440717

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