Cryo electron microscopy of inactive hyaluronan synthase with UDP-GlcNAc
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ABSTRACT:
SUBMITTER: Jochen Zimmer
PROVIDER: EMPIAR-11031 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structure, substrate recognition and initiation of hyaluronan synthase.
Maloney Finn P FP Kuklewicz Jeremi J Corey Robin A RA Bi Yunchen Y Ho Ruoya R Mateusiak Lukasz L Pardon Els E Steyaert Jan J Stansfeld Phillip J PJ Zimmer Jochen J
Nature 20220330 7904
Hyaluronan is an acidic heteropolysaccharide comprising alternating N-acetylglucosamine and glucuronic acid sugars that is ubiquitously expressed in the vertebrate extracellular matrix<sup>1</sup>. The high-molecular-mass polymer modulates essential physiological processes in health and disease, including cell differentiation, tissue homeostasis and angiogenesis<sup>2</sup>. Hyaluronan is synthesized by a membrane-embedded processive glycosyltransferase, hyaluronan synthase (HAS), which catalyse ...[more]
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