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Cryo-EM Structure of the Hyperpolarization-Activated Potassium Channel KAT1

ABSTRACT:

SUBMITTER: Michael Clark

PROVIDER: EMPIAR-11054 | biostudies-other |

REPOSITORIES: biostudies-other

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Electromechanical coupling in the hyperpolarization-activated K+ channel KAT1.

Clark Michael David MD Contreras Gustavo F GF Shen Rong R Perozo Eduardo E

Nature 20200527 7814

Voltage-gated potassium (Kv) channels coordinate electrical signalling and control cell volume by gating in response to membrane depolarization or hyperpolarization. However, although voltage-sensing domains transduce transmembrane electric field changes by a common mechanism involving the outward or inward translocation of gating charges1-3, the general determinants of channel gating polarity remain poorly understood4. Here we suggest a molecular mechanism for e ...[more]

PMID: 32461693

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