Ontology highlight
ABSTRACT:
SUBMITTER: Umeharu Ohto
PROVIDER: EMPIAR-11056 | biostudies-other |
REPOSITORIES: biostudies-other
Asami Jinta J Kimura Kanako Terakado KT Fujita-Fujiharu Yoko Y Ishida Hanako H Zhang Zhikuan Z Nomura Yayoi Y Liu Kehong K Uemura Tomoko T Sato Yumi Y Ono Masatsugu M Yamamoto Masaki M Noda Takeshi T Shigematsu Hideki H Drew David D Iwata So S Shimizu Toshiyuki T Nomura Norimichi N Ohto Umeharu U
Nature 20220517 7916
Chronic infection with hepatitis B virus (HBV) affects more than 290 million people worldwide, is a major cause of cirrhosis and hepatocellular carcinoma, and results in an estimated 820,000 deaths annually<sup>1,2</sup>. For HBV infection to be established, a molecular interaction is required between the large glycoproteins of the virus envelope (known as LHBs) and the host entry receptor sodium taurocholate co-transporting polypeptide (NTCP), a sodium-dependent bile acid transporter from the b ...[more]