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Structure of bile acid transporter NTCP


ABSTRACT:

SUBMITTER: Umeharu Ohto 

PROVIDER: EMPIAR-11056 | biostudies-other |

REPOSITORIES: biostudies-other

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Chronic infection with hepatitis B virus (HBV) affects more than 290 million people worldwide, is a major cause of cirrhosis and hepatocellular carcinoma, and results in an estimated 820,000 deaths annually<sup>1,2</sup>. For HBV infection to be established, a molecular interaction is required between the large glycoproteins of the virus envelope (known as LHBs) and the host entry receptor sodium taurocholate co-transporting polypeptide (NTCP), a sodium-dependent bile acid transporter from the b  ...[more]

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