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Single particle cryo-EM dataset of the Paranosema locustae ribosome bound to Lso2

ABSTRACT:

SUBMITTER: Jonas Barandun

PROVIDER: EMPIAR-11076 | biostudies-other |

REPOSITORIES: biostudies-other

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Differences in structure and hibernation mechanism highlight diversification of the microsporidian ribosome.

Ehrenbolger Kai K Jespersen Nathan N Sharma Himanshu H Sokolova Yuliya Y YY Tokarev Yuri S YS Vossbrinck Charles R CR Barandun Jonas J

PLoS biology 20201030 10

Assembling and powering ribosomes are energy-intensive processes requiring fine-tuned cellular control mechanisms. In organisms operating under strict nutrient limitations, such as pathogenic microsporidia, conservation of energy via ribosomal hibernation and recycling is critical. The mechanisms by which hibernation is achieved in microsporidia, however, remain poorly understood. Here, we present the cryo-electron microscopy structure of the ribosome from Paranosema locustae spores, bound by th ...[more]

PMID: 33125369

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