Dataset Information
Human amino acid transporter EAAT2
Ontology highlight
ABSTRACT:
SUBMITTER: Osamu Nureki
PROVIDER: EMPIAR-11084 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structural insights into inhibitory mechanism of human excitatory amino acid transporter EAAT2.
Nature communications 20220811 1
Glutamate is a pivotal excitatory neurotransmitter in mammalian brains, but excessive glutamate causes numerous neural disorders. Almost all extracellular glutamate is retrieved by the glial transporter, Excitatory Amino Acid Transporter 2 (EAAT2), belonging to the SLC1A family. However, in some cancers, EAAT2 expression is enhanced and causes resistance to therapies by metabolic disturbance. Despite its crucial roles, the detailed structural information about EAAT2 has not been available. Here, ...[more]
