Human amino acid transporter EAAT2
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ABSTRACT:
SUBMITTER: Osamu Nureki
PROVIDER: EMPIAR-11084 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structural insights into inhibitory mechanism of human excitatory amino acid transporter EAAT2.
Kato Takafumi T Kusakizako Tsukasa T Jin Chunhuan C Zhou Xinyu X Ohgaki Ryuichi R Quan LiLi L Xu Minhui M Okuda Suguru S Kobayashi Kan K Yamashita Keitaro K Nishizawa Tomohiro T Kanai Yoshikatsu Y Nureki Osamu O
Nature communications 20220811 1
Glutamate is a pivotal excitatory neurotransmitter in mammalian brains, but excessive glutamate causes numerous neural disorders. Almost all extracellular glutamate is retrieved by the glial transporter, Excitatory Amino Acid Transporter 2 (EAAT2), belonging to the SLC1A family. However, in some cancers, EAAT2 expression is enhanced and causes resistance to therapies by metabolic disturbance. Despite its crucial roles, the detailed structural information about EAAT2 has not been available. Here, ...[more]
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