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Micrographs of IAPP (amylin) amyloid fibrils


ABSTRACT:

SUBMITTER: Gunnar F Schröder 

PROVIDER: EMPIAR-11093 | biostudies-other |

REPOSITORIES: biostudies-other

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Cryo-EM structure of islet amyloid polypeptide fibrils reveals similarities with amyloid-β fibrils.

Röder Christine C   Kupreichyk Tatsiana T   Gremer Lothar L   Schäfer Luisa U LU   Pothula Karunakar R KR   Ravelli Raimond B G RBG   Willbold Dieter D   Hoyer Wolfgang W   Schröder Gunnar F GF  

Nature structural & molecular biology 20200615 7


Amyloid deposits consisting of fibrillar islet amyloid polypeptide (IAPP) in pancreatic islets are associated with beta-cell loss and have been implicated in type 2 diabetes (T2D). Here, we applied cryo-EM to reconstruct densities of three dominant IAPP fibril polymorphs, formed in vitro from synthetic human IAPP. An atomic model of the main polymorph, built from a density map of 4.2-Å resolution, reveals two S-shaped, intertwined protofilaments. The segment 21-NNFGAIL-27, essential for IAPP amy  ...[more]

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