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Single-particle cryo-electron microscopy final particle stacks and .star files from TSHR complexes

ABSTRACT:

SUBMITTER: Aashish Manglik

PROVIDER: EMPIAR-11120 | biostudies-other |

REPOSITORIES: biostudies-other

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Publications

Autoantibody mimicry of hormone action at the thyrotropin receptor.

Faust Bryan B Billesbølle Christian B CB Suomivuori Carl-Mikael CM Singh Isha I Zhang Kaihua K Hoppe Nicholas N Pinto Antonio F M AFM Diedrich Jolene K JK Muftuoglu Yagmur Y Szkudlinski Mariusz W MW Saghatelian Alan A Dror Ron O RO Cheng Yifan Y Manglik Aashish A

Nature 20220808 7928

Thyroid hormones are vital in metabolism, growth and development1. Thyroid hormone synthesis is controlled by thyrotropin (TSH), which acts at the thyrotropin receptor (TSHR)2. In patients with Graves' disease, autoantibodies that activate the TSHR pathologically increase thyroid hormone activity3. How autoantibodies mimic thyrotropin function remains unclear. Here we determined cryo-electron microscopy structures of active and inactive TSHR. In inactive TSHR, th ...[more]

PMID: 35940205

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