Dataset Information
Single-particle cryo-electron microscopy final particle stacks and .star files from TSHR complexes
Ontology highlight
ABSTRACT:
SUBMITTER: Aashish Manglik
PROVIDER: EMPIAR-11120 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Autoantibody mimicry of hormone action at the thyrotropin receptor.
Nature 20220808 7928
Thyroid hormones are vital in metabolism, growth and development<sup>1</sup>. Thyroid hormone synthesis is controlled by thyrotropin (TSH), which acts at the thyrotropin receptor (TSHR)<sup>2</sup>. In patients with Graves' disease, autoantibodies that activate the TSHR pathologically increase thyroid hormone activity<sup>3</sup>. How autoantibodies mimic thyrotropin function remains unclear. Here we determined cryo-electron microscopy structures of active and inactive TSHR. In inactive TSHR, th ...[more]