Dataset Information
Single particle cryo-EM dataset of sarkosyl-insoluble fraction from the cingulate cortex of an individual with Parkinson's disease dementia -synuclein filaments
Ontology highlight
ABSTRACT:
SUBMITTER: Yang Yang
PROVIDER: EMPIAR-11140 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structures of α-synuclein filaments from human brains with Lewy pathology.
Nature 20220915 7933
Parkinson's disease (PD) is the most common movement disorder, with resting tremor, rigidity, bradykinesia and postural instability being major symptoms<sup>1</sup>. Neuropathologically, it is characterized by the presence of abundant filamentous inclusions of α-synuclein in the form of Lewy bodies and Lewy neurites in some brain cells, including dopaminergic nerve cells of the substantia nigra<sup>2</sup>. PD is increasingly recognised as a multisystem disorder, with cognitive decline being one ...[more]