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Cryo-EM dataset of Candida albicans CIII, inhibitor free

ABSTRACT:

SUBMITTER: John L Rubinstein

PROVIDER: EMPIAR-11149 | biostudies-other |

REPOSITORIES: biostudies-other

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Rieske head domain dynamics and indazole-derivative inhibition of Candida albicans complex III.

Di Trani Justin M JM Liu Zhongle Z Whitesell Luke L Brzezinski Peter P Cowen Leah E LE Rubinstein John L JL

Structure (London, England : 1993) 20210914 1

Electron transfer between respiratory complexes drives transmembrane proton translocation, which powers ATP synthesis and membrane transport. The homodimeric respiratory complex III (CIII<sub>2</sub>) oxidizes ubiquinol to ubiquinone, transferring electrons to cytochrome c and translocating protons through a mechanism known as the Q cycle. The Q cycle involves ubiquinol oxidation and ubiquinone reduction at two different sites within each CIII monomer, as well as movement of the head domain of t ...[more]

PMID: 34525326

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